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Effectiveness of a Home-based Approach to Child Contact Investigation and Tuberculosis Preventive Treatment Management by Community Health Workers in Ethiopia: A Pragmatic Cluster-randomized Trial

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Authors: Nicole Salazar-Austin, Silvia Cohn, Bareng A S Nonyane, Christiaan Mulder, Fiseha Mulatu, Samuel Bayu, Moges Bizuayehu, Gidea Conradie, Akash Malhotra, Paul Phan, Natalia Hernandez Morfin, Stephanie Borsboom, Petros Mitiku, Demissu Fulas, Mulunesh Tulema, Jonathan E Golub, Richard E Chaisson, Gavin Churchyard, Ahmed Bedru

This study looked at whether community health workers visiting families at home could help more children start treatment to prevent tuberculosis. Compared to standard clinic-based care, home visits led to about 40% more children beginning preventive treatment, with similar completion and safety outcomes in both groups. While the difference was not statistically certain, the results suggest home-based care could help protect more children from TB, especially in high-burden settings.

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Resource Topic: Tuberculosis

Resource Type: Cluster Randomized Trial

Year: 2025

Region: Sub-Saharan Africa (SSA)

Country: Ethiopia

Publisher May Restrict Access: No

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