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Community Health Worker–Led Hypertension Management with Independent Prescribing in Rural Lesotho: A Cluster-Randomised Non-Inferiority Trial

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Authors: Felix Gerber, Giuliana Sanchez-Samaniego, Ravi Gupta, Thabo Ishmael Lejone, Thesar Tahirsylaj, Fabian Raeber, Iliana Esquivel, Elis Belen Saavedra, Malebona Mathulise, Thuso Kabi, Mosoetsi Mokaeane, Malehloa Maphenchane, Manthabiseng Molulela, Makhebe Khomolishoele, Mota Mota, Manthati Mofokeng, Mamoronts’ane Pauline Sematle, Lebohang Sao, Mosa Tlahali, Malitaba Litaba, Dave Brian Basler, Kevin Kindler, Irene Ayakaka, Pauline Grimm, Thilo Burkard, Frédérique Chammartin, Alain Amstutz, Niklaus Daniel Labhardt

This study in rural Lesotho looked at whether trained community health workers could safely manage high blood pressure, including adjusting patients’ medicines, instead of relying only on nurses at health facilities. The study involved 807 adults across 103 villages and found that after one year, blood pressure was controlled in 77.7% of people receiving care from CHWs compared with 73.5% receiving usual nurse-led care. There were also no important differences in serious side effects between the two groups. The findings suggest that trained CHWs can safely help manage high blood pressure in communities and improve access to long-term care.

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Resource Topic: CHW Role, Hypertension

Resource Type: Cluster Randomized Trial

Year: 2026

Region: Sub-Saharan Africa (SSA)

Country: Lesotho

Publisher May Restrict Access: No

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